yes, you should turn your headunit down to 3/4 power. The volume on your headunit increases/decreases the 'preamp output voltage' of the headunit.
Basically, it increases the signal. Then your amp takes that signal and amplifies it (multiplies it).
So if your headunit is at full volume and puts out 5v, the amp sees that 5v, and times it by the gain you set it to.
If your headunits at 3/5 volume it would put out 3v, and you would set your amp's gain higher to compensate for the difference.
You do not want to put your headunit at full volume, because it causes 'clipping'. The rule of thumb is to set your headunit's volume to 3/4, and don't ever go past that. Because your headunit 'stresses' itself to putout the extra power, and the signal isn't as clear as it is at lower volumes. This is particularly bad, because your amplifier amplifies all of the mistakes found in the preamp signal.
Play a 50hz test tone, with the sub speaker wires NOT plugged into the amp. I like to play a few tones to adjust the subsonic filter, low pass, and just to adjust the gain.
30hz tone to set my subsonic filter, once the voltage your DMM sees starts dropping, your filter has reached that tone (30hz).
60hz for the lp.
you can mess around with it and do what you feel comfortable doing. your voltage shouldn't go over your amp's RMS. Don't go by max power, ever. Completely discard any max power rating you ever see. As its a useless number that represents nothing.